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  1. Thanks for a great video. These videos are huge yield. However, I'd like to ask; I keep hearing in videos on G-protein coupled receptors that upon ligand binding, the GDP gets 'replaced' by GTP. Is this the correct way to phrase this step or would it be more correct to say that the GDP gets phosphorylated to GTP? Thanks.

  2. Quick question–at 14:53, for the HAVe1M&M mnemonic, should the alpha receptor be listed as alpha1, rather than alpha 3?

    Thanks again for making these!

  3. its really amazing…………………….highly useful ……………the way you designed the video make me more interesting

  4. GPCRs are found in yeast, choanoflagellates, and animals. Ligands that bind and activate GPCRs include light-sensitive compounds, odors, pheromones, hormones, and neurotransmitters, and range from small molecules, peptides to large proteins.

  5. tht is something i was finding actualyy
    thanks for this!
    i will be more grateful if u take me out of one puzzle plz:(
    the querry is, that Gq n Gs both are stimulatory ok? so where s the diff? that Gq cause vasoconstriction nd Gs cause vasodilation! ????

  6. THANK YOU!! That helped a lot! I understand the thing now. Thank you very much and good luck with your residency…

  7. Good work with the explanation, it cleared my concept but it would have been better if you had helped us in memorising the physiologic functions of each one as well, I find that pretty tough !

  8. its awesome for the very first time im very much clear about signaling mechanism…thank u thank u so much.

  9. I think it's helpful to note that the separation of the beta/gamma complex increases the alpha's affinity for GTP… perhaps helpful to me at least :[

  10. YOU ARE MY HERO! I am finishing my 3rd week of med school and we got taught 5 of these types of pathways in less than 2 hours. That did NOT stick in my brain.This video was great, now I am going to see if you have one on MAPK, PI3K/Akt, and Wnt/B-catenin!

  11. That was AWESOME! In less than 20 mins you managed to deliver the information that our doctors fail to deliver in a 2 hrs lecture! THANK YOU!

  12. our proffesor made G protiens dificult to understand but u helped a lot………after watchig it i realized that its not that dificult……thnks a .loooooooooooooooooooooooooooooooooooooooooooooooooooooooooooot sir…

  13. Clear and concise video on GPCR! Your mnemonics are very helpful for long term use past the Boreds – ie useful on Rounds too! Thanks so much. I hope you are at a Teaching Hospital and Medical students are able to benefit from your knowledge and expertise at explaining that knowledge to others.
    God Bless you! I’m a retired physician and we didn’t know much of what we now know in terms of molecular biology and it’s applications to clinical medicine. But Med school taught me how to learn and so I continue to learn! Thanks for being a part of another physician’s education. You are fulfilling the Oath!
    Thank you. God Bless!

  14. Amazing explanation , but i have checked the channel , there are very less videos , hope to get more about all other receptor . GABA ,D , H , …etc , as well as the Mechanism .

    Once we understand all the receptors , the later will be easy to remember all the medication uses and side effects

  15. This is the clearest, easiest and most detail-oriented explanation for this topic. I literally stood up from my sit to give a standing ovation 'cause that's the least I could do! 🙌

  16. Great vid overall pointing out the high yield info just a minor note though @14:47 for the Gq mneumonic it says alpha 3 instead of alpha 1 🙂

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