Resolving the Vitamin D-Bate
Articles Blog

Resolving the Vitamin D-Bate

October 8, 2019

“Resolving the Vitamin D-Bate” Is there a way we can ask the body
how much vitamin D it wants overall? Scientists came up with two ways. First, let’s say you give a whopping
dose, and I mean whopping: 100,000 IUs, something that could
be toxic if done on a daily basis. The question is, what’s our
body’s saturation point? Of this massive dose, how much
does our body actually use, and how much does it sock away in storage
for use later on down the road? Here’s the graph: 30 people, followed for
four months after the megadose. Here’s the flood of D
coming into their system. But the solid circles represent the
pool of vitamin D our body is keeping in our bloodstream for activation, and the rest is likely stored away to be
used on an as-needed ongoing basis. Note that in this setting of abundance, the body is keeping our levels right
around that sweet spot dip found in the U-shaped mortality curve. You can do the same thing at
the other end of the spectrum, too. Instead of a megadose, you can
start by giving really tiny doses and gradually work your way up. When you do, you get a graph like this,
showing a so-called biphasic pattern: really steep at first,
but then leveling out. When you take in just a little bit,
your body zips it into circulation, desperately needing it. But then, as you increase the dose, at a certain point you
kind of turn the corner. When the crisis is averted, your body seems happy enough with
your levels that as you take more in, your levels still rise, but it’s
not such an emergency. Now if this plateau were flat,
completely horizontal, then there’d be no risk of toxicity. But because your body
can’t help but let some in, your levels continue to rise
with increasing intake, and you can run into vitamin D
toxicity problems if we take too much. But what’s this level here,
right at the corner, where your body takes a big sigh of relief that you’re doing pretty
good on vitamin D? Working in from both ends, the level at which our
body appears satisfied translates to about 2,000 IUs a day,
which should get us right into that U-shaped longevity sweet spot— whereas the Institute of Medicine
recommendation appear too low, and the 10,000 IU recommendation
put forth by others appears too high.

Only registered users can comment.

  1. disappointing,. really messy and lazy, not a good summary of the research or for that matter physiology of vitamin d.

Leave a Reply

Your email address will not be published. Required fields are marked *