Articles

Vitamin D vs Disease (HD) (CC)

December 10, 2019


Like. Share. Subscribe. [music] [music] Vitamin D is a fat-soluble vitamin our bodies
require for good physical and mental health. And while vitamin D is most famous for its
bone building benefits, it is also one of nature’s greatest interventions
against many common chronic diseases. These include diabetes, high blood pressure, dementia, and even cancer. We’ll start by exploring the evidence of
vitamin D’s ability to prevent glucose intolerance and diabetes. [music] Animal studies, using rodents bred to be diabetic,
and given vitamin D throughout their lives, have been shown to have an 80% lower risk
of developing diabetes, despite their genetics. Human studies have had similar results. In the study, ‘Intake of vitamin D and risk
of type 1 diabetes: a birth-cohort study’, children receiving 2000 IU of vitamin D from
their first year onward also decreased their risk of getting type
1 diabetes by 80%. A study published in Endocrine Society’s
Journal of Clinical Endocrinology & Metabolism proved that people who have low levels of
vitamin D are more likely to have type 2 diabetes, whether they are obese or at a normal, healthy
weight. A quote: “Numerous observational studies (mostly
cross-sectional, but some longitudinal) demonstrate a consistent association of low
serum vitamin D levels with diabetes, pre-diabetes, metabolic syndrome, obesity,
and fat content (adiposity). This relationship is noted in adults and in
children, in both sexes, and in various ethnic backgrounds.” Numerous vitamin D studies have also established
that the more you weigh, regardless of age, the more vitamin D your body needs. One example is a population-based epidemiological
study from Norway, originally published in the European Journal
of Nutrition and Pediatric Diabetes. The study demonstrated the strong inverse
association between elevated body mass index (also known as “BMI”) and serum vitamin D levels. The higher the weight, the lower the vitamin
D levels. A quote: “In children and adolescents, the association seems more consistent and prominent. More than 50% of Norwegian children and adolescents with excess body weight had a low vitamin D status, and 19% had vitamin D deficiency.” The Norwegian study backed up other similar studies on the subject. Later studies confirmed that high Body Mass Index and low vitamin D levels go hand in hand. Furthermore, there is proof that you can decrease your chances of developing diabetes by supplementing with vitamin D, even if you are obese. These studies helped to confirm the theory
that obesity was not the cause of diabetes in the obese, vitamin D deficiency is. As I stated earlier, vitamin D is a fat-soluble
nutrient. This means we store it in our body’s fat. The more fat you have the more vitamin D gets stored, instead of immediately used. For this reason, the more you weigh, the more vitamin D your body requires. But we’ll discuss that more thoroughly later. [music] Multiple studies, some going back to the late 1990’s, have demonstrated that vitamin D can help
lower blood pressure. To understand how vitamin D is able to affect blood pressure, it’s important to know that vitamin D receptors are distributed throughout the human body. This includes Cardiomyocytes, which are muscle cells; Endothelium, the thin tissue that lines the
interior of blood vessels and lymphatic vessels. And Vascular Smooth Muscle Cells, which provide structural integrity to blood vessel walls, and regulate the diameter of blood vessels
by contracting and relaxing dynamically in response to vasoactive stimuli (otherwise known as blood pressure). In one of the oldest studies, published in
the UK medical journal Lancet, the researchers reported that hypertension
patients exposed to UVB radiation for 3 months had an 180% increase in circulating concentrations of 25-hydroxyvitamin D – the major circulating form of vitamin D. And a 6 point decrease
in their diastolic and systolic blood pressures; results similar to what one would expect if
the patients had been given a blood pressure medication. Many other studies have backed up those findings, and also proven that UVA radiation is not
able to stimulate vitamin D synthesis in our skin. In one of these later studies, published in
Journal of Clinical Investigation, a similar group of patients who were exposed to UVA radiation experienced no increase in circulating concentrations of 25-hydroxyvitamin D, and continued to
be hypertensive throughout the 3-month study. The exact mechanism by which UVB radiation was able to return blood pressure levels to normal, in the hypertensive adults studied, is not
well understood, but the observation made in the study titled
“1,25-dihydroxyvitamin D3 is a negative endocrine regulator of the renin-angiotensin
system,” shed some light on the question. In that study it was observed that 1,25-dihydroxyvitamin D3 was effective in down-regulating renin and angiotensin, which naturally decreases
blood pressure. There’s more detailed information about
the study in the article ‘Vitamin D Versus High Blood Pressure’. The link is in the description box below. [music] The research community has known for decades
that very low vitamin D levels increases one’s risk of Alzheimer’s disease, and other forms of dementia. A large Italian study, conducted from 1998
to 2006, concluded that low vitamin D levels increased one’s risk of developing Alzheimer’s disease. And it wasn’t the only one to reach this
conclusion. According to Dr. Herbert Harris, “Low vitamin D concentrations have been
associated with impairments in cognitive functions such as memory and orientation, executive
function impairments, and Alzheimer’s disease. … Persons with severe vitamin D deficiency (20 ng/ml), the odds of VaD were increased by 3.8-fold
only. Pearson correlation showed that serum vitamin D was inversely associated with systolic and diastolic blood pressure in vitamin D-deficient subjects. Since the combined presence of hypertension and vitamin D deficiency increases the probability of developing VaD, screening for vitamin D
status in addition to regular monitoring of blood pressure, could reduce the risk of VaD associated with cerebral SVD in the elderly Asian Indian subjects.” To summarize, while you are more likely to
suffer from vascular dementia if you are vitamin D deficient, and even more so if you are hypertensive,
your chances of developing vascular dementia skyrocket if you are both. [music] Numerous clinical studies have established
that the lower your serum vitamin D levels the greater your odds of dying from cancer. Reports published in the journals Lancet,
Preventative Medicine, and Cancer Causes Control, have demonstrated that people living at higher latitudes in the United States and Europe are at an
increased risk of dying from colon, prostate and breast cancers. Endocrinologists have known for more than a decade that less sunlight means an increased risk of developing and dying from certain kinds of cancers. According to Dr. Michael F. Holick, a leading expert on the topic, “One of the most intriguing important and
unappreciated biologic functions of 1,25-dihydroxyvitamin D3 is its ability to down-regulate hyperproliferative cell growth. Normal and cancer cells that have a vitamin D receptor often respond to 1,25-dihydroxyvitamin D3 by decreasing their proliferation and
enhancing their maturation. This was the rationale for using 1,25-dihydroxyvitamin D3 and its analogs to treat the common hyperproliferative skin disorder psoriasis.” Based on the studies compiled in the book
Biologic Effects of Light 2001, more than 25% of the deaths due to breast
cancer in European women could be attributed to the women’s lack of UVB radiation from
sunlight exposure. However, it’s not just women who are affected. “Both men and women are at a higher risk
of dying of cancer if they have minimum exposure to sunlight.” There’s evidence that a lack of UVB exposure can lead to earlier development of prostate cancer. “In a retrospective study, [it was] reported
that men on average begin to develop prostate cancer by the age of 52 years, whereas men exposed to more sunlight throughout
their lives did not begin developing prostate cancer until 3-5 years later.” A 2006 study, published in the Journal of
the National Cancer Institute, also concluded “Low levels of vitamin D
may be associated with increased cancer incidence and mortality in men, particularly for digestive system cancers. The vitamin D supplementation necessary to achieve a 25-hydroxyvitamin D increment of 25 nmol/L may be at least 1500 IU/day.” More recent studies have also concluded that vitamin D status can indeed be a determining factor in whether one will develop and/or
survive cancer. I’ve quoted the study conclusions published in the journal Current Medical Research and Opinion. “Research strongly supports the view that
efforts to improve vitamin D status would have significant protective effects against
the development of cancer. The clinical research community is currently revising recommendations for optimal serum levels and for sensible levels of sun exposure, to levels greater than previously thought. Currently, most experts in the field believe
that intakes of between 1000 and 4000 IU will lead to a more healthy level of serum
25(OH)D, at approximately 75 nmol/L that will offer
significant protection effects against cancers of the breast, colon, prostate, ovary, lungs,
and pancreas. The first randomized trial has shown significant protection against breast cancer, and other clinical trials will follow and
ultimately lead to improved public health policies and significantly fewer cancers.” FYI, the dosage recommendations suggested
in the 2008 study, I just quoted, differs from what is currently
being recommended by researchers. More on that later. [music] Research has shown that the very young and very old have an elevated risk for vitamin D deficiency. The elderly are at risk because, as we get
older, we become less active and spend less time in the sun. Also our skin becomes less efficient at manufacturing sufficient quantities of vitamin D. Newborns and toddlers, on the other hand,
are often protected from direct sunlight by sunscreen, hats and shaded strollers. And, according to the American Journal of
Clinical Nutrition, there has been a resurgence in vitamin D deficiency among “neonates and young children, in part because of the campaign to encourage all women to provide all of their infants’ nutrition through breastfeeding. [There] is very little, if any, vitamin D
in human milk. [And] infants, especially infants of women
of color, are at high risk of developing vitamin D deficiency and rickets if they are not given a vitamin D supplement.” People of color, regardless of age, are at
the greatest risk for vitamin D deficiency, because they have more melanin in their skin. Everyone living in the higher latitudes, particularly the Snowbelt, has an elevated risk of vitamin D deficiency, if they aren’t taking steps to insure adequate intake. But dark skinned people living in the Sunbelt can still be at risk, if they don’t take advantage of the year round sunshine. [music] According to the findings of the study, “Volumetric dilution, rather than sequestration best explains the low vitamin D status of obesity,” an adult of normal weight requires 5,000 IU/day for life. This amount was calculated based on weight, with four goals in mind: 1. The dose must be easy to obtain at most
pharmacies 2. Will get at least 97% of people above 30
ng/ml 3. Will get most people above 40 ng/ml, and close to around 50 ng/ml 4. Will not cause anyone to get toxic levels Vitamin D Council founder, Dr. John Cannell
spoke to one of that study’s authors, Robert Heaney, and based on that conversation he offers the best explanation of how the study’s authors calculated the flat amount, and how you can calculate an amount to fit
your own individual needs. “For those who want a more careful calculation, he stated his data showed that 70-80 IU/day/kg of body weight total input is needed to obtain a 25-hydroxyvitamin D of 40 ng/ml. That works out to about 35 IU/day/pound. So a 100 pound woman would need 3,500 IU/day of total input but a 300 pound lineman would need 10,500 IU/day. Keep in mind this is total input, which includes
sunlight, diet and supplements.” [music] We are always better off getting our nutrients from their natural sources rather than supplements, but sometimes we require a little help. This has proven especially true for vitamin
D and people living at higher latitudes. Those of us living in these areas of the world are simply not capable of getting enough sunlight. This means we will have to take extra measures to insure we get enough vitamin D. Those extra measures can be supplements or a UVB tanning bed. Obviously, one is more immediately affordable than the other. And not all vitamin D supplements are equal. According to Dr. Joseph Mercola, “Studies have even concluded that vitamin
D2 should no longer be regarded as a nutrient appropriate for supplementation or fortification of foods (though it continues to be used).” If you do choose to supplement, choose vitamin
D3. Why D3? It’s the form of vitamin D that your body
produces when you are exposed to sunlight or a UVB tanning bed. Some foods also contain vitamin D, but most
are not vegan-friendly. Topping the list is oily fish – these include
salmon, swordfish, trout, mackerel, tuna, halibut, herring and sardine. Raw eels are also rich in vitamin D. Egg yolks, caviar, pork spare ribs and even lard all contain vitamin D. The only plant foods that contains vitamin
D, to my knowledge, are mushrooms. Portabello, maitake, morel, and chanterelle
are all good sources. And since mushrooms absorb vitamin D from the sun, like all other earth organisms, exposing your mushrooms to direct sunlight for an hour or more before eating will help to insure you get the maximum amount of vitamin D that they can provide. For more information on Vitamin D’s ability
to prevent diabetes, high blood pressure, dementia and cancer, visit our blog Holistic Health & Living. Links to all four articles are in the description box below. [music] If you’d like to see more videos on individual nutrients, like and share this video with your social network. If you have any questions or comments about this video, post it below or email me at [email protected], tweet me on Twitter, or post to our Google+ page. Subscribe to Holistic Health & Living to receive
email updates each time we upload a new video. [music]

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